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Related Experiment Video

Updated: Jan 6, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Microbial bile acid modifications: current understandings, key problems, and future perspectives.

Haobo Zhang1, Jiejie Wen1, Xiang Liu1,2

  • 1Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Science China. Life Sciences
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PubMed
Summary
This summary is machine-generated.

The gut microbiota significantly modifies bile acids (BAs) through various pathways. Targeting the microbiota-bile acid axis offers promising therapeutic strategies for disease management.

Keywords:
bile acid modificationbile acidsgut microbiotagut microbiota-bile acid axis

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Area of Science:

  • Microbiology
  • Metabolism
  • Physiology

Background:

  • The gut microbiota plays a crucial role in modifying bile acids (BAs).
  • Microbial BAs influence human physiology and are implicated in various diseases.
  • Understanding the microbiota-BA axis is key for therapeutic interventions.

Purpose of the Study:

  • To review microbial transformations of bile acids.
  • To explore the association between microbial-modified BAs and human physiology.
  • To investigate therapeutic strategies targeting the microbiota-BA axis.

Main Methods:

  • Literature review of microbial BA modifications.
  • Analysis of microbial species and enzymes involved in BA metabolism.
  • Examination of therapeutic strategies and emerging research tools.

Main Results:

  • Gut microbes perform diverse BA modifications including deconjugation, 7α-dehydroxylation, and re-conjugation.
  • Microbial BAs modulate physiological functions via canonical and non-canonical receptors.
  • Therapeutic strategies include regulating microbial composition and inhibiting BA modifications.

Conclusions:

  • The gut microbiota-BA axis is a significant modulator of human health.
  • Targeting this axis holds substantial potential for novel disease management approaches.
  • Emerging tools are advancing the discovery of novel BA modifications and their roles.