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Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Updated: Jul 8, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Unmasking complex polymerization interferences in multiple myeloma diagnostics: A case study.

Dan Han¹, Emily A Wolters¹, Folagbayi K Arowolo¹

¹Icahn School of Medicine at Mount Sinai, Department of Pathology, Molecular and Cell-Based Medicine, 1425 Madison Avenue, 8th Floor, Room 8-52, New York, NY 10029, United States of America.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|October 20, 2025

Summary

This summary is machine-generated.

A case of IgG-lambda multiple myeloma mimicked biclonal gammopathy due to polymerized lambda free light chains (FLC). Dithiothreitol (DTT) treatment resolved assay interferences by disrupting FLC lambda polymers, improving diagnostic accuracy.

Area of Science:

Hematology
Clinical Chemistry
Immunology

Background:

Monoclonal gammopathies are diagnosed using SPEP, IFE, and FLC assays.

Keywords:

Dithiothreitol Lambda light chain Multiple myeloma Protein electrophoresis Protein polymerization

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