Foslevodopa-foscarbidopa infusion
Duncan Street1, Lara Teare1, Andrea Lindahl1
1Department of Neurology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
Practical Neurology
|October 20, 2025
Summary
Continuous subcutaneous foslevodopa-foscarbidopa infusion (CSFFI) offers a new way to manage advanced Parkinson's disease. This therapy may overcome limitations of current treatments, improving patient outcomes.
Area of Science:
- Neurology
- Pharmacology
- Medical Devices
Background:
- Advanced Parkinson's disease presents challenges with oral levodopa, leading to motor fluctuations and dyskinesias.
- Current non-oral treatments like DBS, LCIG, and apomorphine have limited accessibility in specialist centers.
Purpose of the Study:
- To present experience and practical insights on delivering Continuous Subcutaneous Foslevodopa-Foscarbidopa Infusion (CSFFI) service in the UK National Health Service.
- To highlight the advantages of CSFFI compared to other device-aided treatment options for advanced Parkinson's disease.
Main Methods:
- The study details the implementation and management of a CSFFI service.
- It includes a framework for initiating and maintaining treatment and managing side effects.
- Patient cases are used to illustrate the practical application of the therapy.
Main Results:
- CSFFI addresses the unmet need for continuous dopaminergic stimulation in advanced Parkinson's disease.
- The service provides a practical approach to managing complex patient cases.
- Advantages of CSFFI over alternative treatments are discussed.
Conclusions:
- CSFFI is a viable therapeutic option for managing advanced Parkinson's disease.
- The framework provided can guide the establishment of CSFFI services.
- Effective management of side effects is crucial for successful CSFFI therapy.
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