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Augmenting bioactivity of in-situ captured Gd3+/Dy3+co-doped bio-glass by bisphosphonated chitosan-reinforced polyvinyl alcohol hydrogel scaffold with osteogenic and angiogenic features

  • 0Centre for Nanoscience and Technology, Pondicherry University, Puducherry, 605 014, India.
Carbohydrate Polymers +

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October 21, 2025

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October 21, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

New multifunctional hydrogels offer a promising treatment for critical bone defects. This advanced material promotes bone healing, enables real-time drug monitoring, and provides non-invasive imaging capabilities for enhanced patient care.

Area Of Science

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background

  • Critical-sized bone defects pose significant clinical challenges.
  • Conventional treatments have limited efficacy for severe bone regeneration.
  • Multifunctional hydrogels present a novel therapeutic approach for bone disorders.

Purpose Of The Study

  • To fabricate a novel 3D porous composite hydrogel for bone defect treatment.
  • To investigate the osteogenic potential and mechanical properties of the developed hydrogel.
  • To evaluate the hydrogel's capabilities for drug delivery and multimodal imaging.

Main Methods

  • Fabrication of a 3D porous composite hydrogel using PVA/chitosan integrated with S53P4 bio-glass.
  • Binary doping with Gd³⁺/Dy³⁺ to enhance material properties.
  • Loading hydrogel with alendronate for sustained drug release and evaluating apatite formation in simulated body fluid (SBF).
  • Assessing MG63 cell proliferation and mineralization.
  • Evaluating MRI, CT contrast, and fluorescence imaging potential.

Main Results

  • The fabricated 10GDBGPC hydrogel exhibited superior mechanical strength and porosity.
  • Sustained alendronate release was observed, promoting significant apatite formation after 21 days in SBF.
  • Enhanced MG63 cell proliferation and mineralization were evident over the 21-day culture period.
  • The hydrogel demonstrated multifunctional imaging capabilities, including enhanced T1 and T2 MRI, CT contrast, and visible fluorescence.

Conclusions

  • The developed Gd³⁺/Dy³⁺ doped S53P4 bio-glass integrated PVA/chitosan hydrogel shows significant potential for treating critical bone defects.
  • The hydrogel facilitates osseointegration, allows real-time drug release monitoring, and enables non-invasive imaging.
  • This integrated approach advances hydrogel applications in regenerative medicine and biomedical imaging.

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