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Related Experiment Video

Updated: Jan 14, 2026

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications
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Bioactive binary Schiff-base hydrogel from chitosan and functional PEGylated dialdehydes: Synthesis and

Zesheng Song1, Xun Wang1, Bingrong Liu2

  • 1School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China.

Carbohydrate Polymers
|October 21, 2025
PubMed
Summary

Researchers developed novel bioactive hydrogels from functionalized polyethylene glycol (PEG) and chitosan (CS) for infected wound healing. These Schiff-base hydrogels offer rapid gelation, self-healing, and antibacterial properties, with tailored performance for specific biomedical needs.

Keywords:
AntibacterialChitosanPEGylated dialdehydeSelf-healing hydrogelWound healing promotion

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Bioactive hydrogels are essential for managing infected wounds due to their gelation, mechanical strength, and antibacterial properties.
  • Developing advanced hydrogels with tailored functionalities is crucial for improving wound healing outcomes.

Purpose of the Study:

  • To synthesize and characterize novel Schiff-base self-healing hydrogels using functionalized polyethylene glycol (PEG) dialdehydes and chitosan (CS).
  • To evaluate the biocompatibility, mechanical properties, antimicrobial activity, hemostasis, self-healing, and specific therapeutic performances of the developed hydrogels for infected wound management.

Main Methods:

  • Three functional PEGylated dialdehydes (SY-PEG, GA-PEG, IM-PEG) were synthesized and cross-linked with chitosan (CS) to form Schiff-base hydrogels.
  • Characterization included assessments of gelation time, mechanical strength (tensile, compressive), swelling rate, tissue adhesion, antioxidant capacity (DPPH assay), antimicrobial activity, and in vitro infected wound healing efficiency.

Main Results:

  • All synthesized hydrogels (SY-PEG/CS, GA-PEG/CS, IM-PEG/CS) exhibited good biocompatibility, strong antimicrobial activity (>95%), rapid hemostasis (<100 s), and self-healing properties.
  • SY-PEG/CS showed rapid gelling (29.3 s) and high antioxidant capacity (81.6%).
  • GA-PEG/CS demonstrated superior swelling (170.5%), mechanical strength (80.3 kPa tensile, 1595 kPa compressive), and wound healing efficiency (82.0% in 7 days).
  • IM-PEG/CS exhibited the highest tissue adhesion strength (233 kPa).

Conclusions:

  • Customizing functional PEGylated dialdehydes allows for the creation of Schiff-base hydrogels with tunable properties for specific biomedical applications.
  • These functional hydrogels show significant potential for effective infected wound management, offering a versatile platform for advanced therapies.