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Recent developments in polysaccharide-based conductive hydrogels: A review and perspective.

Lijun Liu1, Yanbo Wang1, Xianwei Li1

  • 1Medical Supplier Center of PLA General Hospital, Beijing 100853, China.

Carbohydrate Polymers
|October 21, 2025
PubMed
Summary

Polysaccharide-based conductive hydrogels offer promising solutions for wound healing due to their biocompatibility and electrical properties. This review explores their applications from antibacterial effects to scar repair, highlighting future research directions.

Keywords:
Electrical stimulationPolysaccharide materialsPolysaccharide-based conductive hydrogelWound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Polysaccharides are natural, bioactive, and biodegradable polymers gaining traction for hydrogel development.
  • Polysaccharide-derived conductive hydrogels exhibit excellent electrical conductivity and biocompatibility, making them suitable for wound healing applications.

Purpose of the Study:

  • To review recent advancements in polysaccharide-based conductive hydrogels for wound healing.
  • To provide an overview of different types of polysaccharide conductive hydrogels and their characteristics.
  • To summarize applications in wound healing stages and discuss future research directions.

Main Methods:

  • Literature review of polysaccharide-based conductive hydrogels.
  • Categorization of hydrogels based on polysaccharide source (chitosan, cellulose, starch, cyclodextrin, alginate, hyaluronic acid).
  • Analysis of hydrogel characteristics and wound healing applications.

Main Results:

  • Overview of various polysaccharide conductive hydrogels including chitosan, cellulose, starch, cyclodextrin, alginate, and hyaluronic acid-based materials.
  • Detailed discussion of key hydrogel characteristics relevant to wound healing.
  • Summary of applications across wound healing phases: antibacterial effects, cell migration/proliferation promotion, and scar repair.

Conclusions:

  • Polysaccharide-based conductive hydrogels show significant potential in wound healing applications.
  • Further research is needed to address current challenges and optimize hydrogel design for advanced wound care.
  • These materials offer a promising avenue for developing next-generation wound healing therapies.