Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

972
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
972
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

12.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
12.0K
Neural Regulation01:37

Neural Regulation

43.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.1K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.4K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroimmune lipidome dysregulation in major depressive disorder: A meta-analysis of peripheral endocannabinoid and N-acylethanolamine signaling.

Brain, behavior, and immunity·2026
Same author

Evaluating the Causal Relationship between Personality and Parkinson's Disease.

Current neurovascular research·2026
Same author

Comparative anatomy and metabolic profiles of brown and white adipose tissue in humans.

Frontiers in endocrinology·2026
Same author

Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping.

PloS one·2026
Same author

Individualized prediction of survival after brain metastasis development in patients with breast cancer.

Journal of neuro-oncology·2026
Same author

Cross-Platform and cross-species lipidomic profiling identifies promising biomarkers for adolescent major depressive disorder.

Molecular psychiatry·2026

Related Experiment Video

Updated: Jan 14, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

8.0K

Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease.

Ziyao Zhang1, Hongbao Cao2, Ancha Baranova2,3

  • 1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Brain and Behavior
|October 21, 2025
PubMed
Summary

This study identified six circulating inflammatory proteins linked to Parkinson's disease (PD) risk. Some proteins may protect against PD, while others increase susceptibility, offering new therapeutic targets.

Keywords:
GWASGene‐Drug Interaction AnalysisMendelian randomizationParkinson's diseasecirculating inflammatory proteins

More Related Videos

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.0K

Related Experiment Videos

Last Updated: Jan 14, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
12:49

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

8.0K
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

2.0K

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Inflammation plays a key role in Parkinson's disease (PD) pathogenesis.
  • Identifying circulating inflammatory proteins associated with PD is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To investigate the causal relationship between circulating inflammatory proteins and the risk of developing Parkinson's disease.
  • To identify potential therapeutic targets for PD based on associated inflammatory proteins.

Main Methods:

  • A two-sample Mendelian randomization (MR) analysis was conducted using genome-wide association study (GWAS) data.
  • Examined the effects of 91 circulating inflammatory proteins on PD risk in a large cohort.
  • Utilized inverse variance weighted (IVW), weighted median, and MR-Egger methods, with IVW as the primary approach.

Main Results:

  • Six circulating inflammatory proteins were significantly associated with Parkinson's disease.
  • TNFRSF9, Flt3L, and TGF-α showed a protective effect against PD.
  • IL-18, CD6, and IL-17A were associated with an increased risk of PD.

Conclusions:

  • Several circulating inflammatory proteins contribute to the pathogenesis of Parkinson's disease.
  • These findings provide novel insights into PD mechanisms and potential therapeutic strategies.
  • Identified specific proteins for further investigation in PD drug development.