Related Experiment Video
Updated: Jan 14, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Transition-Metal-Free Interrupted-Hydrogen-Borrowing Methylenation of Ketones Using Methanol
Monalisa Akter1, Pazhamalai Anbarasan1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai - 600036, India.
Abstract:
An efficient and benign base-promoted interrupted-hydrogen-borrowing methylenation of ketones has been developed using methanol under transition-metal- and additive-free conditions. This protocol facilitates access to various 1,5-diketones and functionalized cyclopentane derivative in good to excellent yields. Conversion of 1,5-diketones to functionalized pyridine and dibenzo[c,h]acridine derivatives and one-pot access of former has also been achieved. Plausible mechanisms have been proposed based on preliminary mechanistic investigations and isolation of a possible trapped intermediate.
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