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Updated: Jan 14, 2026
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
The complicated relationship between inflammation and metabolic dysfunction
Shima Abtin1, Tayebeh Ziveh2, Mostafa Rezaee-Tavirani3
1Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
The prevalence of metabolic diseases, including obesity, type 2 diabetes, cardiovascular diseases, metabolic syndrome, and non-alcoholic fatty liver disease, is rising steadily and has emerged as a global health issue. Evidence indicates that chronic inflammation plays a crucial role in the development and progression of metabolic diseases. This review article addresses the intricate and reciprocal link between chronic inflammation and disrupted glucose and lipid metabolism. Furthermore, it explores the influence of factors such as the gut microbiome, socio-psychological variables, and aging. The article ultimately discusses future research directions and the need for a better understanding of the complexities between inflammation and metabolism. Addressing these factors could provide effective strategies for preventing and managing metabolic disorders, improving quality of life and public health.
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