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Updated: Jan 14, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Fast and easy reactor-based production of copper-64 with high molar activities using recoil chemistry
Martin Pressler1,2, Christoph Denk1,3, Hannes Mikula1
1Institute for Applied Synthetic Chemistry, TU Wien, 1060 Vienna, Austria. veronika.rosecker@tuwien.ac.at.
Abstract:
Reactor-based production of medically relevant 64Cu is only possible using recoil chemistry. We report highly soluble tert-butyl copper(II) phthalocyanine as the target material. This enables efficient 64Cu recovery through liquid-liquid extraction after neutron capture. The automatable process allows reuse of the target material and achieves a molar activity of 950 MBq μmol-1.
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