Related Experiment Video
Updated: Jan 14, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A molybdenum-catalyzed acceptorless dehydrogenative approach for quinoline synthesis using amino alcohol
Vaishnavi Atreya1, Anirban Sil2, Debangsu Sil2
1Department of Chemistry, Indian Institute of Technology Jodhpur, Karwar, Jodhpur, 342037, Rajasthan, India. subrata@iitj.ac.in.
Abstract:
We report the bidentate-phosphine-ligand-based molybdenum π-allyl complex [Mo(CO)2(η3-C3H5)(DPPE)Cl] (Mo-1; DPPE = 1,2-bis(diphenylphosphino)ethane) for the dehydrogenative annulation of 2-aminobenzyl alcohol with a wide variety of methylketones to form N-heterocycle quinoline derivatives. The complex Mo-1 also catalyzed the formation of substituted quinolines through the reaction of 2-aminobenzyl alcohol with 1-phenylethanol derivatives. This methodology demands low loading of the complex (1 mol%) and a catalytic base. The process produces water and hydrogen gas as the only byproducts. Thus, the reactions are atom-efficient and environmentally benign.
More Related Videos
Related Concept Videos
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
Aldol Condensation with β-Diesters: Knoevenagel Condensation
Preparation of Alcohols via Addition Reactions
The acid-catalyzed addition of water to the double bond of alkenes is a large-scale industrial method used to synthesize low-molecular-weight alcohols. An acidic atmosphere is required to allow the hydrogen in the water molecule to act as an electrophile and attack the double bond in an alkene. The addition of a proton to the double bond creates a carbocation intermediate. The proton preferentially bonds to the less substituted end of the double bond to create a more stable carbocation...
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Acid Halides to Alcohols: Grignard Reaction
Grignard reagents are a source of carbanions and function as nucleophiles. The mechanism begins with the nucleophilic attack by the carbanion at the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs,...
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...

