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Updated: Jan 14, 2026

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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
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Molecular engineering of NIR AIE probes for cell membrane-targeted cancer phototheranostics
Chengwei Tang1, Wenman Li1, Huixuan Tang1
1School of Pharmacy, School of Basic Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, China. xhchen@gdmu.edu.cn.
Abstract:
A finely engineered NIR AIE probe, namely TTTVPHE, was synthesized with dithieno[2,3-b:2',3'-d]thiophene to bridge triphenylamine and pyridinium units for cell membrane-targeted cancer phototheranostics. TTTVPHE has significant advantages such as strong cell membrane binding affinity, NIR-I/II emission, superior AIE characteristics, and excellent type I/II ROS generation ability.

