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Advanced Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment
Resuscitation
|October 21, 2025
Summary
The International Liaison Committee on Resuscitation (ILCOR) provides updated cardiopulmonary resuscitation (CPR) guidelines. This year
Area of Science:
- Emergency Medicine
- Cardiology
- Critical Care Medicine
Background:
- The International Liaison Committee on Resuscitation (ILCOR) regularly reviews cardiopulmonary resuscitation (CPR) science.
- Comprehensive reviews are published every five years, with annual updates from task forces.
Purpose of the Study:
- To present the 2025 International Liaison Committee on Resuscitation (ILCOR) Consensus on Science (CoS) With Treatment Recommendations (T-R) from the Advanced Life Support Task Force.
- To provide a comprehensive update on resuscitation science reviewed in the past year and since 2020.
Main Methods:
- Continuous review of peer-reviewed cardiopulmonary resuscitation (CPR) science.
- Assessment and debate of evidence certainty using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.
- Inclusion of Justification and Evidence-to-Decision Framework Highlights for transparency.
Main Results:
- Updated recommendations cover defibrillator pad placement, mechanical CPR devices, and mechanical circulatory support.
- Guidance on intravenous vs. intraosseous access, vasopressor use, and hemodynamic targets post-return of spontaneous circulation.
- Specific treatments for cardiac arrest due to hyperkalemia, opioid toxicity, and neuroprotective agents are addressed.
Conclusions:
- The 2025 ILCOR CoS With T-R provides an updated evidence-based consensus on advanced life support.
- Recommendations are informed by rigorous assessment of scientific evidence.
- Priority knowledge gaps for future resuscitation research are identified.
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