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Updated: Jan 14, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms
Xiaolin Hao1,2, Yan Li1,2, Xiaoling Gao3
1Department of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.
Abstract:
Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence. These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.
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