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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
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Calcium score: what do the most reliable guidelines recommend? An analysis using the G-TRUST tool.

Yves-Marie Vincent1, Xavier Gocko2,3, Célia François4

  • 1Department of General Practice, University of Bordeaux, Bordeaux 33000, France.

Family Practice
|October 21, 2025
PubMed
Summary

Reliable clinical practice guidelines (CPGs) recommend against using the coronary calcium score (CSC) for cardiovascular risk assessment in primary prevention. Less reliable guidelines, however, advocate for its use.

Keywords:
cardiovascular diseasecardiovascular riskevaluation methodologypractice guidelineprimary preventionstandard of care

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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Health Policy

Background:

  • Cardiovascular disease (CVD) remains the leading global cause of death.
  • Clinical practice guidelines (CPGs) offer varying recommendations on using the coronary calcium score (CSC) for individual cardiovascular risk assessment.
  • Lack of consensus necessitates evaluating the reliability of CPGs regarding CSC use in primary prevention.

Purpose of the Study:

  • To assess the reliability and relevance of CPGs concerning the use of CSC in primary prevention of cardiovascular disease.
  • To identify which CPGs provide trustworthy recommendations on CSC utilization for risk stratification.

Main Methods:

  • A systematic search of PubMed identified CPGs published between 2018-2023 addressing CSC use in primary prevention.
  • The G-TRUST evaluation grid was employed to assess the quality and reliability of the selected CPGs.
  • CPGs were categorized as 'reliable and relevant' or 'not usable' based on predefined criteria.

Main Results:

  • Out of 467 publications, only seven CPGs met the inclusion criteria for the study.
  • Only two of the seven CPGs were deemed 'reliable and relevant' by the G-TRUST assessment.
  • The remaining five CPGs were classified as 'not usable' due to conflicts of interest, lack of systematic reviews, or absence of patient input.

Conclusions:

  • The two reliable CPGs concluded that the CSC should not be used for cardiovascular risk assessment in primary prevention.
  • Conversely, the five CPGs deemed 'not usable' recommended the use of CSC.
  • The G-TRUST tool effectively evaluates the methodological quality of recommendations, distinguishing reliable guidelines from less dependable ones.