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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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MouseOmics: a multi-omics database for mouse biological study.

Xin Tian1, Yifan Teng2, Miaomiao Huang3

  • 1Key Laboratory of Animal Molecular Nutrition Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Nucleic Acids Research
|October 21, 2025
PubMed
Summary
This summary is machine-generated.

MouseOmics is a new database integrating mouse multi-omics data, including genomes, transcriptomes, and proteomes. This resource supports medical and life science research by providing comprehensive data exploration tools.

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Area of Science:

  • Life Sciences
  • Genomics
  • Proteomics
  • Metabolomics

Background:

  • Mice are crucial models in life sciences, particularly for developmental biology and multi-omics research.
  • A comprehensive, integrated database for mouse multi-omics data is currently unavailable.

Purpose of the Study:

  • To establish MouseOmics, a unified database integrating diverse mouse multi-omics data.
  • To provide user-friendly tools for exploring and analyzing mouse multi-omics information.

Main Methods:

  • Integrated data from 21 genomes, 584 transcriptomes, 285 proteomes, 143 metabolomes, 296 metallomes, and 3 variomes across 5 Mus species and 52 inbred strains.
  • Developed a web interface with functional modules for data exploration.
  • Embedded tools for microsatellite DNA identification (MISAweb) and pathway/gene ontology enrichment analysis.

Main Results:

  • Successfully established MouseOmics, a comprehensive repository of mouse multi-omics data.
  • Implemented user-friendly exploration modules and specialized analysis tools.
  • Enabled convenient online download of multi-omics data.

Conclusions:

  • MouseOmics provides an indispensable resource for researchers in medical and life sciences.
  • The database facilitates in-depth analysis of mouse biology through integrated multi-omics data and tools.
  • Regular updates will ensure MouseOmics remains a current and valuable resource.