An early East Asian lineage with unexpectedly low Denisovan ancestry
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View abstract on PubMed
Summary
This summary is machine-generated.Denisovan ancestry in modern humans varies due to admixture with diverse early human groups. Early East Asians spread Denisovan DNA across Eurasia through gene flow, shaping current genetic diversity.
Area Of Science
- Paleogenomics
- Human Evolution
- Population Genetics
Background
- Denisovan ancestry is unevenly distributed in present-day humans, originating from distinct Denisovan groups.
- Understanding this heterogeneity is key to deciphering early Eurasian modern human population history.
- Post-dispersal population movements and admixture obscure the origins of Denisovan genetic contributions.
Purpose Of The Study
- To investigate the relationship between Denisovan ancestry in ancient and present-day humans.
- To elucidate the origins of Denisovan genetic heterogeneity in Eurasia.
- To reconstruct early modern human population dynamics and admixture events.
Main Methods
- Analysis of ancient DNA from early modern human genomes across Eurasia.
- Comparative genomic analysis of Denisovan ancestry patterns over time.
- Tracing gene flow and admixture events between archaic and modern human populations.
Main Results
- Varying Denisovan ancestry levels in Eurasians result from admixture between diverse early modern human lineages.
- Ancient Japanese (Jomon) individuals show minimal Denisovan ancestry, indicating an ancient East Asian lineage with little Denisovan contribution.
- Early mainland East Asians exhibit the highest Denisovan ancestry in Eastern Eurasia, predating the last glacial maximum and involving multiple Denisovan groups.
Conclusions
- Denisovan ancestry spread across Eurasia primarily through gene flow from early East Asian populations.
- Ancient and present-day genomes reveal continuous Denisovan ancestry sharing, highlighting sustained population interactions.
- This study systematically investigates Denisovan admixture across time, advancing the understanding of Eurasian human population history.
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