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Related Concept Videos

Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

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Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
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Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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A Pharmacokinetic Analysis of Intravenous Fluconazole in Adult Patients Undergoing Mechanical Circulatory Support Device Implantation.

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Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
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Fluconazole exposure during mechanical circulatory support (MCS) device insertion.

Kelly A Cairns1, Kate Morton2, Trisha N Peel3

  • 1Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia; Department of Infectious Diseases, The Alfred Hospital and the School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.

International Journal of Antimicrobial Agents
|October 21, 2025
PubMed
Summary
This summary is machine-generated.

This study found that fluconazole (an antifungal medication) given during mechanical circulatory support (MCS) device insertion achieved therapeutic levels but may not be sufficient against Candida glabrata infections. Further research is needed for optimal antifungal prophylaxis in these patients.

Keywords:
FluconazoleMechanical circulatory support deviceSurgical prophylaxis

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacokinetics

Background:

  • Mechanical circulatory support (MCS) devices are crucial for advanced heart failure management.
  • Invasive Candida infections pose a risk post-MCS device insertion.
  • The role of fluconazole in surgical prophylaxis for MCS procedures is not well-defined.

Purpose of the Study:

  • To assess plasma fluconazole exposure during MCS device insertion.
  • To evaluate Candida species colonization in patients undergoing MCS device insertion.

Main Methods:

  • A pilot pharmacokinetic study was conducted.
  • Perioperative plasma fluconazole levels were measured at four surgical time points.
  • Candida colonization was assessed via swabs.

Main Results:

  • Median fluconazole levels ranged from 3.35 to 3.85 mg/L during the procedure.
  • Fluconazole doses of 200-400 mg IV were administered.
  • Candida parapsilosis, Candida glabrata, and Candida albicans were identified as colonizers.

Conclusions:

  • Fluconazole achieved therapeutic plasma concentrations during MCS device insertion.
  • These levels may be insufficient to prevent Candida glabrata infections.
  • Antifungal prophylaxis strategies require further investigation for MCS patients.