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Toxoplasmosis in South America: a hybridization-driven disease burden?
Lokman Galal1, Aurélien Mercier1, Hélène Yera1
1Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Global Health - Michel Dumas, OmegaHealth, Limoges, France.
Abstract:
Human-mediated migrations have reshaped Toxoplasma gondii in South America through massive hybridizations between Old World domestic lineages and wild native populations. We propose that this convergence of domestic adaptation and virulence traits from wild strains underlies the continent's unusually severe disease burden, particularly ocular toxoplasmosis, with major public health implications.
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