Endoplasmic reticulum stress and oxidative imbalance is the missing link in fibromyalgia pathophysiology

Önder Otlu1, Tuğba Raika Kıran2, Rabia Aydoğan Baykara3

  • 1Department of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye. onder.otlu@ozal.edu.tr.

Scientific Reports
|October 21, 2025
PubMed

Insights

Fibromyalgia syndrome (FMS) involves endoplasmic reticulum (ER) stress and oxidative stress. This study found higher ER stress and oxidative stress markers in FMS patients, suggesting these factors contribute to chronic pain.

Area of Science:

  • Biomedical Science
  • Pathophysiology
  • Chronic Pain Research

Background:

  • Fibromyalgia syndrome (FMS) is a complex chronic pain disorder with unclear pathophysiology.
  • Emerging evidence implicates endoplasmic reticulum (ER) stress and oxidative stress in FMS development.

Purpose of the Study:

  • To investigate the role of ER stress in FMS.
  • To evaluate ER stress and oxidative stress markers in FMS patients.
  • To explore the relationship between ER stress and oxidative stress in FMS.

Main Methods:

  • Included 44 FMS patients and matched healthy controls.
  • Measured serum ER stress markers using ELISA.
  • Assessed oxidative stress markers to correlate with ER stress.

Main Results:

  • Significantly elevated ER stress parameters in the FMS group compared to controls.
  • Elevated oxidative stress markers observed in FMS patients.
  • Demonstrated a strong interconnection between ER stress and oxidative stress in FMS.

Conclusions:

  • ER stress plays a critical role in FMS pathophysiology.
  • ER stress likely exacerbates FMS via oxidative stress mechanisms.
  • Targeting ER and oxidative stress pathways offers potential therapeutic strategies for FMS.

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