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Estimating comparative effectiveness using Single-Arm trials: A challenge in the field of agnosticism

Shang Cao1, Hongwei Kan1, Mingliang Lu2

  • 1Department of Medical Review, Yangtze River Delta Center for Drug Evaluation and Inspection of National Medical Products Administration, Shanghai, China.

BMC Medical Research Methodology
|October 22, 2025
PubMed
Abstract

Keywords:
BiasEfficacy evaluationSingle-arm trialStatistical principle

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