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Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?
Xiaoning Wang1,2,3,4, Kui Fu1,2,3,4, Ying Zhang5,6,7,8
1Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
Purpose:
To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.
Design:
Single-center, retrospective, observational study.
Design:
Single-center, retrospective, observational study.
Main Outcome Measures:
The primary outcome was the clinical pregnancy rate (CPR).
Results:
After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).
Conclusion:
Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.
Trial Registration:
None.
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