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aPhyloGeo: a Python application for correlating genetic and climatic conditions.

Ana Laura Chenoweth Galaz1,2, Nadia Tahiri2

  • 1Department of Mathematics, University of Sonora, 83000, Sonora, Mexico.

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Summary
This summary is machine-generated.

This study introduces aPhyloGeo, a Python application for linking genetic diversity with environmental data. It helps identify genetic adaptations to specific climates using reproducible workflows.

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Area of Science:

  • Evolutionary biology
  • Phylogeography
  • Genomics

Background:

  • Investigating the link between environmental variation and genetic diversity is crucial in evolutionary biology.
  • Understanding species' genetic adaptations to specific environments requires correlating genetic and climatic data.
  • Integrated and reproducible workflows are essential for accurate analysis.

Purpose of the Study:

  • To develop a novel application, aPhyloGeo, for analyzing correlations between genetic variation and environmental data.
  • To provide a robust and reproducible computational framework for phylogeographic research.
  • To facilitate the identification of genetic adaptations to environmental factors.

Main Methods:

  • Developed aPhyloGeo, an open-source Python application.
  • Integrated sequence alignment, phylogenetic inference (sliding window), and statistical tests (Mantel, Procrustean randomization).
  • Implemented multicore processing for efficient data analysis.

Main Results:

  • aPhyloGeo enables the investigation of genetic variation within a phylogenetic framework.
  • Identified mutation hotspots strongly associated with environmental variables.
  • Provided a reproducible pipeline for evaluating localized genomic variation and climatic distribution relationships.

Conclusions:

  • aPhyloGeo offers a comprehensive solution for exploring genotype-environment correlations.
  • The application supports reproducible research in evolutionary biology and phylogeography.
  • Facilitates the discovery of adaptive genetic variations across environmental gradients.