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Contemporary Review of Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant Mitral

Asra Butt1, Gift Echefu1, Derek Geeslin2

  • 1Division of Cardiovascular Diseases, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, United States of America.

Current Cardiology Reviews
|October 22, 2025
PubMed

Insights

Transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS) with concomitant mitral stenosis (MS) shows worse outcomes with severe MS. Mild to moderate MS does not significantly impact TAVR outcomes, but more research is needed.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • Multivalvular disease increases mortality compared to isolated valve disease.
  • Double valve surgery for aortic and mitral stenosis has poorer outcomes, especially in high-risk patients.
  • Transcatheter therapies are being explored for multivalvular disease, but data on TAVR for AS with MS is limited.

Purpose of the Study:

  • To investigate the prevalence and outcomes of transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS) and concomitant mitral stenosis (MS).
  • To evaluate the impact of mitral stenosis severity on TAVR outcomes in patients with AS.

Main Methods:

  • A systematic literature search of PubMed and Cochrane databases was conducted.
  • Included studies and meta-analyses focused on patients undergoing TAVR for severe AS with concomitant MS.

Main Results:

  • Patients undergoing TAVR for AS with MS are typically elderly with degenerative valve disease.
  • Outcomes, including hospital stay and 1-year mortality, are worse in TAVR patients with severe MS.
  • TAVR outcomes in patients with mild to moderate MS show no significant difference compared to TAVR for isolated AS.

Conclusions:

  • Severe concomitant MS is associated with worse outcomes in patients undergoing TAVR for AS.
  • Mild to moderate MS does not significantly affect TAVR outcomes.
  • Further high-quality clinical trials are needed due to limitations in current research on TAVR for combined AS and MS.
Abstract

Keywords:
Transcatheter aortic valve replacementcardiovascular mortalitymitral valve areamitral valve stenosismultivalvular cardiac diseasetrans-mitral mean gradient

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