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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Betamethasone transdermal administration combined with fractional Er:YAG lasers or microplasma radiofrequency technology improved hypertrophic scars: A retrospective study.

Journal of cosmetic dermatology·2024
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Related Experiment Video

Updated: Jan 14, 2026

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas
09:31

Investigating Scarless Tissue Regeneration in Embryonic Wounded Chick Corneas

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Research progress on scar-free healing.

Wenhui Yang1, Liu Liu2, Xingjian Cheng1

  • 1Department of Dermatology and Plastic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China.

Annals of Medicine
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Achieving scar-free healing requires targeting multiple factors, including key signaling pathways and genes. Immunotherapy offers promising regenerative solutions for improved wound healing outcomes.

Keywords:
Cell targetembryoimmunosuppressionscarless healingsignalling pathwaytissue engineering therapy

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Area of Science:

  • Regenerative Medicine
  • Wound Healing Research
  • Tissue Engineering

Background:

  • Pathological scars cause functional impairment and distress, necessitating regenerative solutions.
  • Embryonic development and some adult models exhibit scar-free healing, offering insights into complete tissue repair without fibrosis.

Purpose of the Study:

  • To review literature on wound healing and scarless healing over the past 25 years.
  • To identify key factors, signaling pathways, and therapeutic targets for achieving scar-free healing.
  • To explore advanced treatments, animal models, and immunotherapy strategies for optimizing wound healing.

Main Methods:

  • Comprehensive literature search of major scientific databases (PubMed/MEDLINE, Embase, Web of Science, CNKI, Wanfang, ChiCTR).
  • Inclusion of studies on wound healing, scarless healing, embryonic healing, immunotherapy, and tissue engineering.
  • Examination of reference lists of key articles to identify additional relevant research.

Main Results:

  • Identified key macroscopic and microscopic factors influencing scarless healing, including fibroblasts, collagen, MMPs, neurological factors, and cytokines.
  • Detailed four critical signaling pathways: SDF-1/CXCR4, Wnt, Ca2+/Rho/ROCK, and Hippo pathways, along with genes like YAP and En1.
  • Reviewed advanced treatments, animal models, and highlighted the potential of combined targeted therapies and immunotherapy.

Conclusions:

  • Scar formation is multifactorial, requiring combined therapeutic approaches targeting signaling pathways and genes.
  • Immunotherapy presents significant potential for scarless healing, warranting further research into its mechanisms.
  • Optimizing wound healing necessitates innovative strategies, including immune-targeted approaches.