Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-particle atomic-scale strain-gradient engineering for high-performance fuel cells.

Nature communications·2026
Same author

Interfacial Lewis Acid Chemistry Enabled by Mesoporous MOFs Toward High-Performance Four-Electron Zinc-Iodine Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Efficient Hydrogen Production from Aqueous Methanol Driven by Microdroplet Interfaces.

Journal of the American Chemical Society·2026
Same author

Mechanochemically Coupled Multidimensional Modulation of Calcium Overload.

ACS nano·2026
Same author

Switching from insertion to conversion for multielectron aqueous vanadium batteries.

Nature materials·2026
Same author

Mesoporous Catalytic-Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Video

Updated: Jun 13, 2026

Atomically Traceable Nanostructure Fabrication
12:35

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

9.2K

High-Precision DNA Nanostructure-Templated Silicification via Modified Silanes.

Bochen Li1, Yongjun Liu1, Haozhi Wang1

  • 1State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|October 22, 2025
PubMed
Summary

Researchers precisely controlled DNA-silica composite shell thickness using organoalkoxysilanes. This method enhances material uniformity and offers tunable surface functionalities for nanotechnological applications.

More Related Videos

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

8.1K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.1K

Related Experiment Videos

Last Updated: Jun 13, 2026

Atomically Traceable Nanostructure Fabrication
12:35

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

9.2K
Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

8.1K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.1K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomaterials Engineering

Background:

  • Structural DNA nanotechnology enables complex nanomaterial fabrication.
  • DNA-silica composites (DSCs) show promise in nanophotonics and nanoelectronics.
  • Precise control over silica shell thickness in DSCs is a significant challenge.

Purpose of the Study:

  • To investigate the impact of organoalkoxysilanes (OASs) on DNA-templated silicification.
  • To achieve nanometer-scale control over silica shell thickness.
  • To enhance the monodispersity and surface functionality of DSCs.

Main Methods:

  • Utilized organoalkoxysilanes (OASs) with varying substituent types and quantities for DNA-templated silicification.
  • Investigated the correlation between OAS substituent characteristics and silica shell thickness.
  • Analyzed the effect of OASs on DSC monodispersity and surface properties compared to tetraethyl orthosilicate (TEOS).

Main Results:

  • Identified a negative correlation between the number of OAS substituents and silica shell thickness, enabling precise control.
  • Tailored OAS variants significantly reduced silica shell thickness (up to 76.7% reduction) and improved DSC monodispersity.
  • Established a positive correlation between substituent steric occupancy ratios and DSC monodispersity.

Conclusions:

  • Developed a method for precise nanometer-scale control over silica shell thickness in DNA-silica composites.
  • Demonstrated enhanced monodispersity and tunable surface functionalities of DSCs using tailored OAS precursors.
  • Provided foundational support for advanced applications of DSCs in nanofabrication and photonic crystal engineering.