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Exploring Silicone-Induced Lupus Through a Case Report.

Georgios A Drosos1, Paraskevi V Voulgari1, Alexandros A Drosos1

  • 1Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Mediterranean Journal of Rheumatology
|October 22, 2025
PubMed
Summary

Silicone implants can trigger lupus, an autoimmune disease, causing severe skin issues. Prompt diagnosis and treatment with steroids and hydroxychloroquine are crucial for managing silicone-induced lupus.

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Area of Science:

  • Immunology
  • Dermatology
  • Materials Science

Background:

  • Silicone compounds are used in various medical implants.
  • Silicone exposure is linked to autoimmune/inflammatory syndromes, including ASIA syndrome.
  • ASIA syndrome can manifest as lupus development.

Purpose of the Study:

  • To present a unique case of severe skin manifestations of silicone-induced lupus.
  • To review the literature on silicone-induced lupus.
  • To emphasize the importance of recognizing silicone-induced ASIA syndrome.

Main Methods:

  • Case report of a 48-year-old woman with bilateral silicone breast implants.
  • Clinical examination revealing extensive skin lesions (erythema, epidermal necrolysis).
  • Laboratory tests including CBC, ANA, anti-Ro/SSA, and anti-Sm antibodies.
Keywords:
ASIA syndromeautoantibodiesautoimmunitylupussilicone implants

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Main Results:

  • The patient presented with severe, widespread skin manifestations post-silicone implantation.
  • Laboratory results were consistent with lupus and silicone-induced ASIA syndrome.
  • Treatment with prednisone and hydroxychloroquine yielded excellent results.

Conclusions:

  • Silicone breast implantation can induce lupus with significant dermatological symptoms.
  • Physicians should be aware of ASIA syndrome symptoms in patients with silicone exposure.
  • Timely diagnosis and treatment are essential for managing silicone-induced lupus.