Related Experiment Video
Updated: Jan 14, 2026
Treatment of Facial Deformities using 3D Planning and Printing of Patient-Specific Implants
Published on: May 23, 2020
Positive Impact of Frontofacial Advancement on Intracranial Volumes in Patients With Syndromic Craniofaciosynostosis
Guillaume Lacroix1, Mélodie-Anne Karnoub2,3, Alexis Wolber1,3
1From the Plastic and Reconstructive Surgery Unit, CHU Lille, Lille, France.
Background:
Le Fort (LF) III midface distraction osteogenesis is one of the main techniques for correcting midface deficiency encountered in craniofaciosynostosis. However, regardless of the technique used, there may be a deterioration in the result, with a recurrence of facial hypoplasia, requiring a new procedure to advance the midface.
Methods:
In this retrospective study, computed tomography scans before and after LF III distraction osteogenesis of 7 patients (3 boys and 2 girls with Crouzon syndrome, 1 boy with Apert syndrome, and 1 boy with Pfeiffer syndrome) were analyzed in vestibular orientation. The ages ranged from 4 to 11 years old. All patients presented with syndromic craniofaciosynostosis with class III malocclusion and proptosis. The 3 cranial fossae were segmented slice by slice, and their volumes were calculated. The total intracranial volume was calculated by summing the volumes of the 3 cranial fossae. The Wilcoxon signed-rank test was used to compare the measured values before and after LF III distraction. A P value of less than 0.05 was considered statistically significant.
Results:
Total intracranial volume significantly increased (6%; P = 0.016) in the total study group. Volumes of the anterior and middle cranial fossae increased insignificantly (22.6%, P = 0.33; 4.8%, P = 0.29). The volume of the posterior cranial fossae insignificantly decreased (0.3%, P = 0.58).
Conclusions:
A significant increase in total intracranial volume after LF III advancement in syndromic craniofaciosynostosis patients was reported.
More Related Videos
04:04Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
10:23Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Related Concept Videos
01:27Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
01:14Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
01:22Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
01:08Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
01:19Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...