Related Experiment Video
Updated: Jan 14, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
Published on: April 28, 2020
Acute Liver Injury With Cholestatic Pattern: An Adverse Effect of Trimethoprim-Sulfamethoxazole
Makhlouf Bannoud1, Lucia Hong1, Maya Ibelaidene1
1Internal Medicine, University of California, Riverside School of Medicine, Riverside, USA.
None:
Trimethoprim-sulfamethoxazole (TMP-SMX), commonly known by the brand name Bactrim, is a combination antibiotic medication that is used to treat a broad spectrum of infections. It is known to be associated with a wide array of adverse reactions, including drug-induced liver injury (DILI). Drug-induced liver injury associated with TMP-SMX more commonly presents with a hepatocellular or mixed liver injury pattern rather than a cholestatic pattern. Here, we present the case of a 52-year-old female patient who presented with jaundice and pruritus after a recent course of TMP-SMX. Labs and imaging revealed cholestatic liver injury without obstruction. Further testing ruled out autoimmune and infectious causes. The patient's condition was resolved within five days of presentation with only supportive care administered. Given the clinical course as well as the exclusion of other likely causes, we concluded that this was a case of TMP-SMX-associated acute liver injury with a cholestatic pattern.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Hepatic Drug Excretion: Influencing Factors
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

