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Hypertension-Related Mortality in Aortic Dissection and Aneurysm: A Retrospective Observational Study

Meenakshi Yathindra1, Aayushi Bhamat2, Onkardeep Kaur3

  • 1Internal Medicine, Kasturba Medical College, Mangaluru, IND.

Cureus
|October 22, 2025
PubMed

Insights

Mortality from hypertension-related aortic aneurysms and dissections has shifted, showing increasing disparities among different demographic groups. Targeted prevention and healthcare access are crucial for addressing these evolving trends in cardiovascular mortality.

Area of Science:

  • Cardiovascular epidemiology
  • Public health
  • Medical statistics

Background:

  • Hypertension is a significant risk factor for cardiovascular mortality.
  • The link between hypertension, aortic aneurysms, and aortic dissection is a critical area of research.
  • Understanding mortality trends is essential for public health interventions.

Purpose of the Study:

  • To analyze mortality trends associated with hypertension as a cause of death, specifically when aortic dissection and aneurysm are contributing factors.
  • To identify and examine demographic disparities in mortality rates related to hypertensive aortic diseases.
  • To assess changes in these mortality patterns over time in the United States.

Main Methods:

  • A retrospective observational study utilized the CDC WONDER database (1999-2020).
  • Data included individuals over 25 years old with hypertension (ICD-10: I10-I15) as the underlying cause and aortic dissection/aneurysm (ICD-10: I71.0) as a contributing cause.
  • Age-adjusted mortality rates (AAMR) and annual percentage change (APC) were calculated and stratified by gender, race, region, and place of death.

Main Results:

  • A total of 20,782 deaths were analyzed, with an initial decline in AAMR followed by a significant increase between 2006-2009, and a subsequent slight decrease.
  • Males, White individuals, those in metropolitan regions, and deaths in medical facilities represented the highest mortality burdens.
  • Temporal analysis revealed increasing AAMR in males and females, and similar trends in African American and White individuals from 2006-2009, highlighting evolving disparities.

Conclusions:

  • Mortality trends for hypertension with aortic dissection and aneurysm show a complex pattern with a notable increase in disparities across demographic groups.
  • The findings emphasize the urgent need for tailored prevention strategies to mitigate cardiovascular mortality.
  • Improving healthcare access is critical to address the identified inequities in outcomes.
Abstract

Keywords:
age-adjusted mortality rateaortic aneurysmaortic dissectionhypertensionretrospective study

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