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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Research advance in correlation between childhood asthma and gut microbiota

Yucong Ma1, Haoqi Zheng2, Hai Tian3

  • 1Department of Pediatric Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.

Frontiers in Cellular and Infection Microbiology
|October 22, 2025
PubMed

Insights

Childhood asthma is linked to gut bacteria. Interventions like probiotics and SCFAs show promise in rebalancing gut microbes and reducing inflammation, offering new treatment avenues.

Area of Science:

  • Pediatric Pulmonology
  • Microbiome Research
  • Immunology

Background:

  • Asthma is a common, complex respiratory condition in children.
  • The gut-lung axis plays a key role in asthma development.
  • Specific gut bacteria, like Lactobacillus and Bifidobacterium, are associated with childhood asthma.

Purpose of the Study:

  • To review evidence on the gut-lung axis and childhood asthma.
  • To explore the potential of microbiota-targeted therapies for asthma.
  • To synthesize findings from human and animal studies.

Main Methods:

  • Literature review of clinical and mechanistic studies.
  • Analysis of research on gut microbiota, probiotics, SCFAs, and phytogenic compounds.
  • Examination of the gut-lung axis in pediatric asthma pathogenesis.

Main Results:

  • Gut microbiota modulation shows promise for asthma management.
  • Probiotic supplementation and short-chain fatty acids (SCFAs) can restore microbial balance and reduce type 2 inflammation.
  • Phytogenic compounds may alter gut microbiota and improve asthma symptoms.

Conclusions:

  • Targeting the gut microbiota offers a promising therapeutic strategy for pediatric asthma.
  • Further research is needed to develop personalized, microbiota-based interventions.
  • Restoring gut microbial homeostasis is crucial for managing childhood asthma.

Keywords:
asthmagut microbiotagut-lung axisimmune modulationpathogenesis

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