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Neonatal Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment
Pediatrics
|October 22, 2025
Summary
The International Liaison Committee on Resuscitation updated neonatal resuscitation guidelines based on the latest science since 2020. This review covers 40 key questions and includes new systematic reviews for infant resuscitation.
Area of Science:
- Neonatal Resuscitation Science
- Cardiopulmonary Resuscitation (CPR) Guidelines
Background:
- The International Liaison Committee on Resuscitation (ILCOR) periodically reviews CPR science.
- The Neonatal Life Support (NLS) Task Force reviews evidence published since 2020 for the 2025 NLS guidelines.
Purpose of the Study:
- To summarize the latest evidence and provide treatment recommendations for neonatal resuscitation.
- To address 40 critical questions related to the Neonatal Resuscitation Algorithm.
Main Methods:
- Systematic and scoping reviews of peer-reviewed cardiopulmonary resuscitation science.
- Evidence assessment using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.
- Consensus treatment recommendations developed by the NLS Task Force.
Main Results:
- Incorporation of 4 new systematic reviews and 2 new scoping reviews.
- Evidence updates on various neonatal resuscitation topics.
- Consensus treatment recommendations based on rigorous evidence evaluation.
Conclusions:
- The 2025 NLS guidelines reflect the most current scientific evidence.
- Identified knowledge gaps for future research in neonatal resuscitation.
- Provides a framework for evidence-based infant resuscitation practices.
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