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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Updated: Jan 14, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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[Ferroptosis: from molecules to diseases].

Xuesong Wang1, Di Kang1, Yingying Wang1

  • 1Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Binzhou Medical University (The First Clinical Medical College), Binzhou 256603, China.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology
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Ferroptosis, a cell death form driven by iron overload and lipid peroxidation, is linked to diseases like cancer and neurodegeneration. Understanding iron metabolism offers new therapeutic strategies.

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Area of Science:

  • Biomedical research
  • Cellular biology
  • Pathophysiology

Background:

  • Ferroptosis is a regulated cell death pathway.
  • Its mechanism involves iron overload-induced lipid peroxidation.
  • Ferroptosis is implicated in neurodegenerative disorders, tumors, and organ damage.

Purpose of the Study:

  • To review research progress on iron's role in biology, metabolism, and regulation.
  • To explore iron's connection to ferroptosis-related diseases.
  • To provide insights for developing new therapeutic strategies targeting ferroptosis.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of high-throughput technologies, genomics, and proteomics data.
  • Synthesis of current knowledge on iron metabolism and ferroptosis.

Main Results:

  • Iron is essential but can induce cell death via ferroptosis.
  • Dysregulation of iron metabolism is central to ferroptosis.
  • Advances in technology are illuminating cellular iron regulation.

Conclusions:

  • Further research into iron biology and metabolism is crucial.
  • Targeting ferroptosis presents potential therapeutic avenues.
  • In-depth molecular studies are needed for new treatment strategies.