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Targeting the CCL2/CCR2 Axis in HIV-1 Infection and Ischemic Stroke

Silvia Torices1, Daniela Iglesias Gallo1, Enrique Lara1

  • 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, FL.

Stroke
|October 22, 2025
PubMed

Insights

People with HIV have a higher risk of ischemic stroke. The CCL2/CCR2 pathway may drive this risk and could be a therapeutic target for stroke prevention in HIV infection.

Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • HIV infection is linked to increased cardiovascular and cerebrovascular events.
  • Ischemic stroke incidence is 3 times higher in people with HIV compared to uninfected individuals.
  • Mechanisms underlying enhanced ischemic stroke risk in HIV remain unclear.

Purpose of the Study:

  • To review the role of the CCL2/CCR2 signaling pathway in HIV infection.
  • To examine the pathway's influence on ischemic stroke outcomes and recovery.
  • To propose the CCL2/CCR2 axis as a potential therapeutic target.

Main Methods:

  • Literature review focusing on the CCL2/CCR2 pathway in HIV and stroke.
  • Analysis of chemokine function in leukocyte recruitment and neuroinflammation.
  • Examination of blood-brain barrier permeability.

Main Results:

  • CCL2/CCR2 signaling mediates leukocyte (CD4+ T cells, monocytes/macrophages) recruitment to the brain.
  • This pathway contributes to neuroinflammation and blood-brain barrier disruption post-stroke.
  • The CCL2/CCR2 axis is implicated in the heightened stroke risk in HIV.

Conclusions:

  • The CCL2/CCR2 pathway plays a significant role in the pathogenesis of ischemic stroke in HIV-infected individuals.
  • Targeting the CCL2/CCR2 axis offers a promising therapeutic strategy for mitigating stroke risk and improving outcomes in people living with HIV.

Keywords:
CCL2HIV-1braininflammationischemic stroke

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