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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Muscle Recovery and Fatigue01:24

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Related Experiment Video

Updated: Jan 14, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

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MS Fatigue Post High-Efficacy Treatment.

C Sales1,2, R Patel2, T Wijeratne3

  • 1ANU College of Law, Governance and Policy, Australian National University, Canberra, Australia.

European Journal of Neurology
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Highly effective therapies (HETs) may reduce multiple sclerosis-related fatigue (MSF) in patients with relapsing-remitting MS (RRMS). Physical fatigue showed the most significant improvement, suggesting neuroinflammation plays a role in MSF.

Keywords:
fatiguehighly effective DMTsmultiple sclerosispatient‐reported outcomesrelapsing–remitting

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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Area of Science:

  • Neurology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a leading cause of disability in young adults.
  • Fatigue affects up to 95% of MS patients, impacting quality of life.
  • The effect of disease-modifying therapies (DMTs) on MS-related fatigue (MSF) is not fully understood.

Purpose of the Study:

  • To investigate changes in fatigue levels in relapsing-remitting MS (RRMS) patients after initiating highly effective therapies (HETs).

Main Methods:

  • Systematic literature search of major databases (MEDLINE, PubMed, Scopus, PsycINFO).
  • Inclusion of studies assessing fatigue in RRMS patients treated with HETs using validated measures.
  • Meta-analysis of extracted data using a random-effects model to calculate standardized mean differences (SMD) in fatigue scores.

Main Results:

  • Eighteen studies with 4138 RRMS patients were analyzed.
  • A small but significant overall reduction in fatigue was observed (SMD = -0.34).
  • Physical fatigue demonstrated significant improvement, particularly with natalizumab and when using the Fatigue Scale for Motor and Cognitive Functions.

Conclusions:

  • Initiation of HETs leads to a decrease in MS-related fatigue, especially physical fatigue.
  • Findings support the role of neuroinflammation in driving MS fatigue.
  • Emphasizes the need for domain-specific research and tailored treatment strategies for MSF.