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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Pulmonary Cytomegalovirus replication in Immunocompetent Hosts: Harmless Bystander or Hidden Threat?
Sergio Venturini1, Ingrid Reffo2, Manuela Avolio3
1Department of Infectious Diseases, ASFO Santa Maria degli Angeli Hospital of Pordenone, Italy.
Abstract:
We investigated CMV DNA pulmonary viral loads in adults in asymptomatic patients without classic immunosuppressive conditions undergoing bronchoalveolar lavage (BAL) for screening non-acute, non-infectious pulmonary diseases with a six-month follow-up. Over 31 months, 73 out of 352 BAL samples (20.7%) tested positive, with wide viral load variability (median 829 copies/mL, IQR 1457 copies/mL). None of the patients received antiviral treatment or developed CMV-related disease during follow-up. Nine patients died during follow-up. Patients presented a range of risk factors, and none was associated with higher VL. These findings suggest that CMV pulmonary behavior deserves further attention across various populations.
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