Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors affecting Blood pressure01:28

Factors affecting Blood pressure

6.5K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
6.5K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.0K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.0K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

6.8K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
6.8K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.7K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.7K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

781
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
781
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

5.9K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-scale modeling of electric vehicle fatal crash risk: uncovering spatial heterogeneity and infrastructure-land use coupling mechanisms.

Accident; analysis and prevention·2026
Same author

Salt priming coordinates transcriptional and epigenetic states for enhanced salt tolerance in mung bean (Vigna radiata).

Communications biology·2026
Same author

Immunometabolic and immune regulatory functions of capsaicin in cancer: mechanistic insights and emerging perspectives.

Frontiers in immunology·2026
Same author

Traversing the ancient Overland Silk Road: Insights from domestic camel paleogenomics in Xi'an, China.

Zoological research·2026
Same author

Secular Trends and Predictors of Frequent Cannabis Use From 2002-2019 in the United States.

Mayo Clinic proceedings·2026
Same author

High-zinc diets accelerate molting and recovery by remodeling the cecal microbiome in laying hens.

Frontiers in microbiology·2026

Related Experiment Video

Updated: Jan 14, 2026

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats
07:35

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats

Published on: January 31, 2019

16.4K

Blood pressure variability compromises vascular function in middle-aged mice.

Perenkita J Mendiola1, Philip O'Herron1, Kun Xie1

  • 1Department of Physiology, Medical College of Georgia, Augusta University, Augusta, United States.

Elife
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Blood pressure variability (BPV) significantly impacts brain health, causing cognitive decline. This study reveals that large BP fluctuations, even without hypertension, impair neurovascular function and worsen cognitive deficits in mice.

Keywords:
autoregulationblood pressurebradycardiccognitivemousemyogenicneuroscienceneurovascular

More Related Videos

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

23.0K
Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
07:54

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry

Published on: May 17, 2016

21.6K

Related Experiment Videos

Last Updated: Jan 14, 2026

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats
07:35

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats

Published on: January 31, 2019

16.4K
Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

23.0K
Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
07:54

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry

Published on: May 17, 2016

21.6K

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Aging Research

Background:

  • Blood pressure variability (BPV) is a risk factor for cognitive decline and dementia.
  • The effects of large blood pressure fluctuations on neurovascular function are not well understood.

Purpose of the Study:

  • To investigate the impact of chronic blood pressure variability on neurovascular function and cognitive performance.
  • To establish a murine model for studying BPV independent of sustained hypertension.

Main Methods:

  • Developed a novel murine model of BPV using intermittent angiotensin II infusions in middle-aged mice.
  • Utilized radio telemetry to monitor blood pressure and two-photon imaging to assess neurovascular responses.

Main Results:

  • Chronic BPV mice showed comparable 24-hour average blood pressure to controls but exhibited cognitive deficits and a blunted bradycardic response.
  • BPV mice displayed heightened myogenic responses in parenchymal arterioles.
  • The pressure-dependent amplification of neurovascular coupling observed in control mice was abolished in BPV mice.

Conclusions:

  • Chronic blood pressure variability impairs neurovascular function, including myogenic responses and neurovascular coupling.
  • BPV is a critical factor contributing to cognitive decline and brain health issues, independent of average blood pressure levels.