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T-Cell Receptor Clonotypes and Aggressive Subtypes in Cutaneous T-Cell Lymphoma

Liliana L Crisan1, Shanpeng J Li2, Michelle Afkhami3

  • 1Division of Dermatology, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California.

JAMA Dermatology
|October 22, 2025
PubMed
Summary

T-cell receptor (TCR) sequencing identified specific clonotypes linked to aggressive mycosis fungoides (MF) and Sézary syndrome (SS). These findings can improve risk stratification for earlier, targeted treatment of MF/SS patients.

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