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Related Experiment Videos

Circumventing the Henderson-Hasselbalch equation.

D R Kamens, R L Wears, C Trimble

    JACEP
    |November 1, 1979
    PubMed
    Summary
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    Quickly assess metabolic status using blood-gas analysis without the Henderson-Hasselbalch equation. New methods simplify determining acid-base balance from pH and PCO2, aiding clinical decisions.

    Area of Science:

    • Clinical Chemistry
    • Acid-Base Balance
    • Respiratory Physiology

    Background:

    • Prompt blood-gas analysis (pH, PCO2, PO2) is widely available.
    • PCO2 indicates respiratory contribution to acid-base disturbances.
    • Metabolic status assessment typically relies on the complex Henderson-Hasselbalch equation (HHE).

    Purpose of the Study:

    • To present two simplified methods for determining metabolic status from pH and PCO2.
    • To avoid the use of the Henderson-Hasselbalch equation for faster clinical assessment.

    Main Methods:

    • Method 1: Adjusting pH to isolate metabolic state by correcting for hyper/hypoventilation.
    • Method 2 (novel): Estimating the bicarbonate ion concentration ([HCO3-]) using measured pH and PCO2.

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    Main Results:

    • The first method, a known technique, effectively isolates the metabolic component of acid-base status.
    • The second, unreported method utilizes pH to estimate the [HCO3-]/PCO2 ratio, directly calculating bicarbonate concentration.

    Conclusions:

    • Simplified methods allow rapid assessment of metabolic status from blood-gas parameters.
    • These approaches offer alternatives to the Henderson-Hasselbalch equation for clinical utility.