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Updated: Jan 14, 2026

Traumatic Peripheral Nerve Injury in Mice
Published on: March 25, 2022
Netrin-1: pioneering new Frontiers in peripheral nerve injury treatment
Chun Qin1,2, Song Zhang3, Guo Hua3
1Graduate School of Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Background:
The incidence of peripheral nerve injury has increased annually and it has become a common traumatic disease in clinical practice.
Methods:
Netrin-1 is a crucial extracellular matrix protein that plays a significant role in nerve development and regeneration, and is involved in the construction of a local neurological injury regional regeneration and repair microenvironment to support axon and myelin repair growth.
Results:
Recent studies have highlighted its important roles in the repair of peripheral nerve injuries.
Conclusion:
This review clarifies how Netrin-1 in fluences neuronal survival, promotes axonal regeneration, and modulates neuro-inflammation.

