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Flow-driven magnetic microcatheter for superselective arterial embolization.

Lucio Pancaldi1, Ece Özelçi1, Mehdi Ali Gadiri1

  • 1Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Science Robotics
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed novel magnetic microcatheters for navigating tiny, hard-to-reach brain arteries. This breakthrough enables new minimally invasive treatments for cerebrovascular conditions previously inaccessible to doctors.

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Area of Science:

  • Biomedical Engineering
  • Interventional Neurology
  • Medical Robotics

Background:

  • Minimally invasive endovascular techniques have transformed cerebrovascular disease treatment.
  • Conventional catheterization is limited by instrument diameter and stiffness, restricting access to distal brain vasculature.
  • A significant portion of the brain's intricate vascular network remains inaccessible for diagnosis and treatment.

Purpose of the Study:

  • To overcome mechanical limitations of conventional catheterization for accessing previously unreachable brain vasculature.
  • To develop and demonstrate the efficacy of novel, ultraminiaturized magnetic microcatheters for endovascular navigation.
  • To enable superselective delivery of agents to distal and tortuous arteries.

Main Methods:

  • Microengineering of inflatable, flat-tube magnetic microcatheters for enhanced flexibility and navigation.
  • Development of a compact magnetic steering platform compatible with biplane fluoroscopy.
  • In vivo testing in a porcine model to assess navigation, tracking, and infusion capabilities.

Main Results:

  • Demonstrated safe and effortless navigation and tracking of arteries as small as 180 micrometers with high curvature.
  • Successfully performed superselective infusion of contrast and embolic liquid agents.
  • The magnetic microcatheters harnessed blood flow for endovascular navigation, overcoming mechanical barriers.

Conclusions:

  • The developed magnetic microcatheter technology provides unprecedented access to distal and tortuous arteries.
  • This innovation holds significant potential for diagnosing and treating cerebrovascular conditions, including aneurysms, strokes, and tumors.
  • The technology can be adapted for targeted drug or gene delivery across various organ systems, enhancing precision and safety.