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Metal-Ligand Bonds02:51

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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Color in Coordination Complexes
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In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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EDTA: Chemistry and Properties01:22

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Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
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Production and Targeting of Monovalent Quantum Dots
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Proton-Resistant Quantum Dots by Ligands.

Xia Zong1, Meixin Liu1, Xinran Xu1

  • 1State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Frontiers Science Center for Cell Responses, National Demonstration Center for Experimental Chemistry Education, Engineering Research Center of Thin Film Optoelectronics Technology, Ministry of Education, Nankai University, Tianjin 300071, P. R. China.

ACS Nano
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Engineered ligands create proton-resistant quantum dots (QDs) by shielding and trapping protons. These advanced QDs maintain stable fluorescence in acidic conditions, enhancing nanomaterial durability.

Keywords:
fluorescencehydrogen bondproton-resistantquantum dotssurface ligand

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Quantum dots (QDs) possess unique optical and electronic properties for various applications.
  • QD surface chemistry critically impacts photoluminescence, especially in acidic environments where protonation causes aggregation and fluorescence quenching.

Purpose of the Study:

  • To develop proton-resistant quantum dots (QDs) using only ligand engineering, avoiding bulky coatings.
  • To investigate a synergistic proton defense mechanism involving electrostatic shielding and proton trapping.

Main Methods:

  • Designed surface ligands with proton-amenable groups (e.g., amino) for electrostatic shielding.
  • Utilized low dielectric constant solvents (e.g., ethylene glycol) to enhance shielding.
  • Incorporated hydrogen-bonding moieties in ligands to trap protons via network formation.

Main Results:

  • Achieved proton-resistant Ag2Se QDs through ligand engineering alone.
  • Demonstrated stable fluorescence retention at proton concentrations up to 0.8 mol/L.
  • Observed a four-orders-of-magnitude improvement in proton tolerance compared to standard QDs.

Conclusions:

  • Ligand engineering offers a universal strategy for creating proton-resistant QDs.
  • This approach advances nanomaterial design for applications in harsh acidic environments.