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Updated: Jan 14, 2026

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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The many faces of the GID/CTLH E3 ligase complex

Arno F Alpi1,2, Jakub Chrustowicz1, Dawafuti Sherpa1

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, 82152, Germany.

Biochemical Society Transactions
|October 22, 2025
PubMed
Summary

The GID/C-terminal to LisH (CTLH) E3 ligase complex is a versatile regulator of cellular processes. Its adaptable structure and regulatory mechanisms offer potential for targeted protein degradation therapies.

Keywords:
E3 ubiquitin ligaseGID/CTLH E3degronhigher-order E3 assemblymolecular glueoligomeric metabolic enzymesubiquitin proteasome system

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