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Mental health and Crohn's disease: evaluating depression through a case-referent study
Juan Manuel Escudero Prados1, Antonio Cortés-Rodríguez1, Marta Elena Losa-Iglesias2
1Universidade da Coruña, Campus Industrial de Ferrol, Faculty of Nursing and Podiatry, Department of Health Sciences, Research, Health and Podiatry Group - Ferrol, Spain.
Objective:
The aim of this study was to compare the frequency and severity of depressive symptoms between adults diagnosed with Crohn's disease and a demographically matched group of healthy individuals. Depressive symptoms were assessed using the Beck Depression Inventory, a validated self-report instrument.
Design And Setting:
The study employed a comparative and exploratory case-control design to evaluate whether patients with Crohn's disease report significantly higher levels of depressive symptomatology than healthy controls. Patients were recruited from various regions in southern Spain.
Methods:
A total of 84 participants were included, comprising 42 individuals with Crohn's disease and 42 matched controls. Assessment of depressive symptoms was performed using the Beck Depression Inventory, a validated instrument for quantifying depression severity. As the data did not meet normality assumptions, non-parametric methods were applied for statistical analysis.
Results:
Crohn's disease patients demonstrated significantly higher depression scores compared to controls (Beck Depression Inventory: 15.55±9.99 vs. 5.76±4.18; p<0.001). The prevalence of depression (Beck Depression Inventory ≥10) was 32.1% in the Crohn's disease group versus 9.5% in the control group. Notably, severe depression was observed exclusively among Crohn's disease patients, highlighting the substantial psychological burden associated with the disease.
Conclusion:
These results highlight the significant psychological burden associated with Crohn's disease, with patients experiencing higher rates and greater severity of depression compared to healthy individuals.
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