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Preparation and performance study of lithium‑zinc doped bio-glass/chitosan/polyacrylamide composite hydrogel loaded with doxorubicin hydrochloride

  • 0Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China.
Biomaterials Advances +

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October 22, 2025

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October 22, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed a novel composite hydrogel for osteosarcoma treatment. The Li/Zn-MBG@DOX/CS/PAM hydrogel promotes bone healing and inhibits cancer cells, offering a promising solution for post-surgery bone defects.

Area Of Science

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background

  • Osteosarcoma resection often leads to significant bone defects, recurrence, and metastasis.
  • Existing treatments face challenges in addressing bone regeneration and tumor control simultaneously.

Purpose Of The Study

  • To synthesize and characterize a novel composite hydrogel for treating bone defects after osteosarcoma surgery.
  • To evaluate the hydrogel's potential for promoting bone repair, inhibiting osteosarcoma cells, and facilitating angiogenesis and antibacterial effects.

Main Methods

  • Synthesis of mesoporous bio-glass doped with Li+ and Zn2+ (Li/Zn-MBG) as a drug carrier for doxorubicin hydrochloride (DOX).
  • Incorporation of drug-loaded Li/Zn-MBG into a chitosan/polyacrylamide (CS/PAM) hydrogel to form Li/Zn-MBG@DOX/CS/PAM.
  • Characterization of the hydrogel's structure, mechanical properties, drug loading/release, and in vitro/in vivo performance.

Main Results

  • The Li/Zn-MBG@DOX/CS/PAM hydrogel exhibited enhanced mesoporous properties, high drug loading (23.95%), and sustained DOX release over 14 days.
  • The hydrogel demonstrated favorable mechanical strength (762.00 kPa), swelling (800-900%), promoted bone marrow stromal cell proliferation, and inhibited osteosarcoma cell growth.
  • In vivo studies showed significant femoral defect healing with minimal inflammation in treated mice.

Conclusions

  • The developed Li/Zn-MBG@DOX/CS/PAM composite hydrogel is a promising multifunctional material for osteosarcoma treatment.
  • It effectively addresses bone defect repair, drug delivery, angiogenesis, and antibacterial needs.
  • This innovative hydrogel holds significant potential for improving clinical outcomes in osteosarcoma patients.

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