The effect of leisure-time physical activities on bone mineral density in postmenopausal women: Systematic review and
Anıl Siyahtaş1, Elif Ünlügedik Sayın2, Döndü Kurnaz3
1Independent Researcher, Istanbul, Türkiye.
Abstract:
The aim of this systematic review and meta-analysis was to evaluate the impact of leisure-time physical activity (LTPA) on bone mineral density (BMD) in postmenopausal women. The protocol was developed according to PRISMA guidelines and registered in PROSPERO. Searches were conducted from January to February 2025 across PubMed, The Cochrane Library, EBSCO, Web of Science, PsycINFO, Scopus, National Thesis Center, TR Index, and Turkiye Clinics search engines. The methodological quality of the studies was assessed using the RoB-2 tool. Data were pooled through meta-analysis, and certainty of evidence was appraised using GRADE. 13 findings of 12 studies with a total sample size of 9836 were included in the meta-analysis. BMD across multiple anatomical sites remained stable in intervention groups, but declined in controls, although differences were not statistically significant (p > 0.05). Subgroup analyses suggested varying effectiveness by activity type, ranking them as follows: Structured physical activity modalities > Tai Chi > Pilates ≈ Handball > Step/Dance. Intervention duration appeared most favorable at 6 months, followed by 3, 12, and 9 months. LTPA does not significantly increase BMD overall in postmenopausal women, yet may help maintain bone mass and exert localized benefits depending on activity type and duration. These findings underscore the potential role of structured exercise in mitigating age-related bone loss, although further high-quality trials are warranted.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

