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Related Experiment Video

Updated: Jan 14, 2026

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

Mid-Term Experience With 1,196 Ozaki Procedures.

Shigeyuki Ozaki¹, Yasuhiro Hoshino², Shinya Unai³

¹Department of Cardiovascular Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.

|October 22, 2025

Summary

This summary is machine-generated.

The Ozaki procedure for aortic valve disease shows stable hemodynamics and good left ventricular remodeling. This aortic valve replacement technique offers low reoperation rates, supporting its continued clinical use.

Keywords:

aortic valve replacement autologous pericardium effective orifice area left ventricular mass regression valve performance

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Area of Science:

Cardiovascular Surgery
Biomaterials Science
Medical Devices

Background:

The Ozaki procedure, utilizing autologous pericardium for aortic valve replacement, was introduced in 2007.
Mid-term outcomes and valve performance data for this technique remain largely unreported.

Purpose of the Study:

To evaluate the longitudinal hemodynamics and left ventricular reverse remodeling following the Ozaki procedure.
To assess reoperation rates and survival in patients who underwent the original Ozaki procedure cohort.

Main Methods:

A cohort of 1,196 patients undergoing the Ozaki procedure between April 2007 and May 2021 was analyzed.
Data included patient demographics, valve pathology, concomitant procedures, clinical outcomes, and echocardiograms.
Longitudinal valve performance was assessed using nonlinear mixed-effects regression, and reoperation/mortality were analyzed using time-to-event methods.

Main Results:

Mean aortic valve gradients remained stable and low (7.4-8.2 mm Hg) over 10 years.
Left ventricular mass index significantly decreased post-procedure (141 to 90 g/m²).
Ten-year survival was 78%, and freedom from reoperation was 92%, with a low but increasing rate of regurgitation (6.6% at 10 years).

Conclusions:

The Ozaki procedure yields a functional aortic valve replacement with sustained low gradients.
Significant left ventricular reverse remodeling and favorable long-term survival and reoperation rates were observed.
While aortic regurgitation increases over time, the overall risk profile supports the continued use of the Ozaki procedure.