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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Changing epidemiology of respiratory pathogens since 2020: Shenzhen case study and global perspectives
Chun Chen1, Houming Liu2, Jiaye Liu3
1Department of Respiratory Medicine, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
None:
The coronavirus disease 2019 (COVID-19) pandemic fundamentally disrupted global respiratory virus epidemiology through widespread non-pharmaceutical interventions. Analysis of a tertiary hospital in Shenzhen (2021-2024) reveals profound alterations in seasonal patterns. Influenza A exhibited multiple atypical peaks including summer circulation, while influenza B showed delayed resurgence with sustained winter activity. Respiratory syncytial virus demonstrated altered seasonality with substantial warm-season transmission replacing traditional winter patterns. World Health Organization (WHO) global surveillance confirmed parallel worldwide trends. Influenza activity collapsed dramatically in 2021 before resurging with irregular timing and unprecedented intensity through 2025. Respiratory syncytial virus exhibited off-season epidemics across multiple regions before gradually re-establishing modified seasonal patterns at elevated baseline levels. These epidemiological shifts resulted from immunity gaps created by reduced viral exposure, staggered lifting of pandemic restrictions across regions, and viral competition dynamics. Emerging technologies including AI-driven prediction models, expanded wastewater surveillance systems, and universal vaccine development offer promising approaches for managing future respiratory disease dynamics in this evolving post-pandemic landscape.
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