Participants' characteristics influencing pupillometry parameters in a community in Japan

This study aimed to investigate the factors influencing pupil diameter in individuals of a community in Japan, contributing to a broader understanding of the potential of pupillometry as a non-invasive and reliable health indicator. We used a pupillometry device, "AiLive," developed by Mecara Inc. The participants were recruited during a sports festival (SPORTEC 2023), where Mecara Inc. hosted a booth event. The primary outcomes were pupillometry parameters, including the size of pupil parameters and velocity parameters. We analyzed the association between the primary outcome and participant characteristics, including age, sex, the presence of disease, and medication usage. Significant differences were observed between pupillometry parameters and age, sex, and having cataracts, notably pupil size parameters, while velocity parameters remained consistent across groups. These results highlight that the size of pupil parameters could be under-adjusted for age, sex, and the presence of cataracts;in contrast, velocity parameters might have potential as a diagnostic support tool without any adjustment of participants' characteristics.