Related Experiment Video

Updated: Jan 14, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

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Successful Treatment of Chronic Active Epstein-Barr Virus Infection Complicated by Cardiomyopathy in an Adult Patient

Kaito Harada1,2, Shino Iwata2, Shinichiro Machida2

  • 1Department of Hematology, Ebina General Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|October 22, 2025
PubMed

Insights

Chronic active Epstein-Barr virus infection (CAEBV) can affect the heart, leading to cardiomyopathy. Successful treatment involved chemotherapy and stem cell transplant, achieving long-term remission in a complex case.

Area of Science:

  • Immunology
  • Cardiology
  • Virology

Background:

  • Chronic active Epstein-Barr virus infection (CAEBV) is a rare, severe condition.
  • CAEBV involves Epstein-Barr virus (EBV)-infected T or natural killer cells.
  • Cardiac complications in CAEBV are uncommon but serious.

Purpose of the Study:

  • To report a case of CAEBV with cardiomyopathy.
  • To highlight diagnostic and therapeutic strategies.
  • To emphasize long-term monitoring for cardiac involvement.

Main Methods:

  • Diagnostic imaging and myocardial biopsy.
  • High-dose cytarabine-based chemotherapy.
  • Reduced-intensity conditioning cord blood transplantation.

Main Results:

  • Diagnosis of EBV-positive T cell infiltration in the myocardium.
  • Achieved complete donor chimerism post-transplant.
  • Patient remained in remission for five years despite transient cardiac issues and EBV reactivation.

Conclusions:

  • Myocardial biopsy is crucial for diagnosing cardiac involvement in CAEBV.
  • Long-term monitoring is essential for CAEBV patients with cardiac complications.
  • Multidisciplinary treatment approach can lead to successful outcomes.

Keywords:
chronic active Epstein-Barr viruscord blood transplantationendomyocardial biopsy

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